Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii.

نویسندگان

  • Stéphane Corvec
  • Laurent Poirel
  • Thierry Naas
  • Henri Drugeon
  • Patrice Nordmann
چکیده

The genetic structures surrounding the plasmid-carried blaOXA-23 oxacillinase gene, encoding resistance to carbapenems, were studied in Acinetobacter baumannii. ISAba1 and the novel element ISAba4 were detected upstream of the blaOXA-23 gene, providing promoter sequences for its expression. These insertion elements were likely involved in transposition processes at the origin of acquisition of this beta-lactamase gene.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 51 4  شماره 

صفحات  -

تاریخ انتشار 2007